[Associations of interleukin gene IL1B-511C/T and IL1RN+8006T/C polymorphisms with coronary artery disease in Chinese population: meta-analysis].

Objective To explore the relationships between the IL1B-511C/T and IL1RN+8006T/C polymorphisms and coronary heart disease (CHD) in Chinese population. Methods We analyzed case-control studies regarding the associations of the IL1B-511C/T and IL1RN+8006T/C polymorphisms with CHD in Chinese population by searching PubMed, EMBASE, VIP Database, Wanfang and China National Knowledge Infrastructure databases. All articles were rigorously evaluated and screened based on the inclusion and exclusion criteria. Meta-analysis was performed using Review Manager 5.3 software. Results Eight case-control studies with a total of 1460 CHD patients and 1547 control subjects met the inclusion criteria. The pooled results from IL1B-511C/T polymorphism showed increased risk in allelic model (OR=1.17, 95%CI=1.04-1.31), recessive model (OR=1.58, 95%CI=1.32-1.90) and homozygote model (OR=1.38, 95%CI=1.09-1.74). But for IL1RN+8006T/C polymorphism, decreased risk was observed in allelic model (OR=0.55, 95%CI=0.43-0.69), dominant model (OR=0.52, 95%CI=0.40-0.66) and heterozygote model (OR=0.51, 95%CI=0.40-0.66). Conclusion The IL1RN+8006T/C polymorphism may play a protective role in CHD. The IL1B-511C/T polymorphism is found to be associated with a significant increased risk for CHD based on our analysis.