Comparative binding properties of the tau PET tracers THK5117, THK5351, PBB3, and T807 in postmortem Alzheimer brains

Laetitia Lemoine,Per-Göran Gillberg,Marie Svedberg,Vladimir Stepanov,Zhisheng Jia,Jinghai Huang,Sangram Nag,He Tian,Bernardino Ghetti,Nobuyuki Okamura,Makoto Higuchi,Christer Halldin,Agneta Nordberg

Comparative binding properties of the tau PET tracers THK5117, THK5351, PBB3, and T807 in postmortem Alzheimer brains

2017

Laetitia Lemoine
Per-Göran Gillberg
Marie Svedberg
Vladimir Stepanov
Zhisheng Jia
Jinghai Huang
Sangram Nag
He Tian
Bernardino Ghetti
Nobuyuki Okamura
Makoto Higuchi
Christer Halldin
Agneta Nordberg

Background The aim of this study was to compare the binding properties of several tau positron emission tomography tracers—THK5117, THK5351, T807 (also known as AV1451; flortaucipir), and PBB3—head to head in the same human brain tissue.

Keywords:

Human brain
Pathology
Medicine
Positron emission tomography
Geriatric psychiatry
Neurology
Monoamine oxidase B
Putamen
Ligand (biochemistry)
Biophysics
temporal cortex
Basal ganglia
Hippocampus
Binding site

Correction
Source
Cite
Save
Machine Reading By IdeaReader

References

Citations