Stereoselective synthesis of the C16–C25 fragment of alchivemycins A and B

Abstract An enantioselective route for the efficient synthesis of the key C16–C25 fragment of alchivemycins A and B is described. The route features an Achmatowicz-type rearrangement of furan and a highly enantio- and diastereoselective dihydroxylation as key reactions.