ИНДИВИДУАЛЬНЫЙ ИММУНОЛОГИЧЕСКИЙ ФЕНОТИП И РИСК РАКА МОЛОЧНОЙ ЖЕЛЕЗЫ У ЖЕНЩИН В ПОСТМЕНОПАУЗЕ

The following immunological phenotypes were described using immunoanalysis of blood serum IgABp, IgA-Es and IgA-Pg in 400 healthy women and 1284 breast cancer (BC) patients: “protective” with the minimal BC risk (OR=0.2–0.6) in which personal IgA-Pg level exceeded both IgA-Bp and IgA-Es; “procarcinogenic” with maximal BC risk (OR=2.1–6.2) in which both IgA-Bp and IgA-Es were higher than IgA-Pg; and two “compensatory” (OR=0.7–1.2) in which IgA-Pg levels exceeded IgA-Bp or IgAEs. Existence of one or the other immunophenotype did not depended from smocking or age. The diff erences in correlations of IgA-Bp with IgA-Es and IgA-Pg were revealed at these immunophenotypes. The results would be helpful in the creation and clinical application of anticarcinogenic vaccines for cancer immunoprevention.