Synthesis of 15-(4-[131I]iodophenyl)pentadecanoic acid (p-IPPA) via tin-precursor using Chloramine-T as an oxidant

A rapid method for the preparation of the radioiodinated 15-(4-iodophenyl)pentadecanoic acid (p-IPPA) was developed. 131I-p-IPPA was obtained from the corresponding tin precursor and 131I-iodide using Chloramine-T as an oxidant in a radiochemical yield of 90 ± 1.4% with a radiochemical purity > 99% when performing the labeling at room temperature within a reaction time of 3 min. The study of dependences on temperature (0, 20 and 80 °C) and reaction time (1, 3, 5, 10 and 30 min) showed no yield increase with higher temperatures and prolonged reaction times but the formation of side products.