WNT signaling in bone development and homeostasis.

The balance between bone formation and bone resorption controls postnatal bone homeostasis. Research over the last decade has provided a vast amount of evidence that WNT signaling plays a pivotal role in regulating this balance. Therefore, understanding how the WNT signaling pathway regulates skeletal development and homeostasis is of great value for human skeletal health and disease. WIREs Dev Biol 2014, 3:489–500. doi: 10.1002/wdev.159 Conflict of interest: Bart O. Williams is a consultant for Amgen. For further resources related to this article, please visit the WIREs website.