Imaging Work-Up for Screening of Paraganglioma and Pheochromocytoma in SDHx Mutation Carriers: A Multicenter Prospective Study from the PGL.EVA Investigators
2013
Context: Recommendations have not been established concerning imaging to screen SDHx mutation carriers for paraganglioma and pheochromocytoma. Objective: Our objective was to compare the performance of gadolinium-enhanced magnetic resonance angiography, contrast-enhanced computed tomography, and [123I]metaiodo-benzylguanidine and somatostatin receptor scintigraphies for detecting head and neck and thoracic-abdominal-pelvic paragangliomas in SDHx mutation carriers. Design and Setting: We conducted a prospective, multicenter study from June 2005 to December 2009 at 23 French medical centers. Patients: A total of 238 index cases or relatives carrying mutations in SDHD, SDHB, or SDHC genes were included. Intervention: Images obtained by each technique were analyzed blind, without knowledge of results from other tests, first in each local center and then centrally. Main Outcome Measures: We evaluated sensitivity, specificity, and likelihood ratios for individual and combinations of tests, the gold standard bei...
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