SARS-CoV-2 spreads to lymph nodes and strongly expands CD4+ TEMRA cells in a patient with mild COVID-19.

A woman with mild Covid-19 developed cervical adenopathy, being diagnosed of Epstein-Barr virus infectious mononucleosis. After a FNAP we demonstrate that SARS-CoV-2 is found in lymph nodes (LNs) even in mild disease along with a strong expansion of terminally differentiated effector memory CD4+T-cells , a cell population that is practically absent in LN.