Audit of efficacy of Coartem TM to clear plasmodium falciparum malaria parasitaemia at single forty-two day follow-up : original research
2004
ligBackground:l/ig A follow-up study was undertaken to assess the efficacy of CoartemlsupgTMl/supg tablets (20 mg artemether
and 120 mg lumefantrine - Novartis South Africa (Pty) Ltd) to clear plasmodium falciparuml/ig malaria parasitaemia
at a single 42-day follow-up, with 42 days being chosen in order to detect early emergence of resistance. The
study was performed at Ndumo Clinic and Mosvold Hospital in the Ingwavuma District of KwaZulu-Natal, South
Africa in January/February 2002.
lbrgligMethod:l/ig The study included 37 patients presenting to Ndumo Clinic and two presenting to Mosvold Hospital with
uncomplicated malaria diagnosed by symptoms and a positive immunochromographic test (ICT) for plasmodium falciparum.l/ig The main outcome measures were Trophozoite counts on thick film and polymerase chain reaction
parasite analysis of blood spot at day 42.
lbrgligResults:l/ig Only 31 of the 37 recruited patients were confirmed to be suffering from malaria by polymerase chain
reaction (PCR). Of the 31, 24 returned for follow-up. One patient had parasitaemia at day 33, but tested negative
at day 42 after re-treatment with Coartem(tm). It was not determined whether this patient was suffering from a
recrudescence or re-infection of falciparum malaria. All the other returning patients tested negative for falciparum
malaria on blood film and PCR examination.
lbrgligConclusions:l/ig CoartemlsupgTMl/supg still appears to be an effective treatment for falciparum malaria. Regular assessment
of its efficacy is desirable.
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