Assessment influence of recombinant interleukin-2 and polyoxidonium to physiological condition and formation of non-specific resistance of calves 30 days of age

The basis of health and the possibility of realizing productive potential of farm animals are high level of natural resistance and immune status of their body. One of the reserves for increasing the productivity of young cattle is increase their resistance, especially in conditions of unbalanced feeding of mother cows and violations of the animal housing. The study period of 20-30 days of age of the calves was chosen taking into account the fact that during this period they have reduced resistance to infectious diseases, because immunoglobulins received with maternal colostrum, breaking by this age, and their own are just beginning to be produced. Active immunity is formed only by 1.5-2 months of age. The calves organism needs at this time stimulation of the immune system and nonspecific resistance, and the effect of immuno modulating drugs is more pronounced. The objective of the study was to assess the effect of recombinant interleukin-2 and polyoxidonium on the physiological state, morphological composition of the blood and the formation of nonspecific resistance of calves. The calves of the first experimental group were parenterally injected with recombinant interleukin-2. The calves of the second experimental group were injected polyoxidonium. The calves of the control group were injected physiological saline. The experimental part was performed on calves at farming enterprise Dalnekonstantinovsky district of Nizhny Novgorod region, Russia. The experimental work was conducted in the spring.