Genomic Characterization of a Metastatic Alveolar Rhabdomyosarcoma Case Using FISH Studies and CGH+SNP Microarray Revealing FOXO1-PAX7 Rearrangement with MYCN and MDM2 Amplification and RB1 Region Loss

Arivarasan Karunamurthy,Lori Hoffner,Jie Hu,Peter H. Shaw,Sarangarajan Ranganathan,Svetlana A. Yatsenko,Urvashi Surti

Genomic Characterization of a Metastatic Alveolar Rhabdomyosarcoma Case Using FISH Studies and CGH+SNP Microarray Revealing FOXO1-PAX7 Rearrangement with MYCN and MDM2 Amplification and RB1 Region Loss

2016

Arivarasan Karunamurthy
Lori Hoffner
Jie Hu
Peter H. Shaw
Sarangarajan Ranganathan
Svetlana A. Yatsenko
Urvashi Surti

Rhabdomyosarcomas (RMS) are rare, heterogeneous, soft tissue sarcomas and a common type of childhood malignancy with a distinct histomorphology. At the molecular level, alveolar rhabdomyosarcoma (ARMS

Keywords:

SNP array
Molecular biology
Biology
Genetics
Fluorescence in situ hybridization
Fusion gene
PAX7
Malignancy
Alveolar rhabdomyosarcoma
Chromosomal translocation
FOXO1
Mdm2
Soft tissue

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