Bisphosphonate-related osteonecrosis of the jaw: Current clinical significance and treatment strategy review.

PURPOSE This review paper is intended to provide updated information about the significance of bisphosphonate-related osteonecrosis of the jaw (BRONJ) related to dental departments and also to provide treatment information. However, it does not review anti-resorptive related osteonecrosis of the jaw (ARONJ). METHODS PubMED was searched for published articles on BRONJ that have particular relevance to clinical aspects in orthodontics, endodontics, periodontics, prosthodontics, oral and maxillofacial surgery, implants and treatment planning. In vitro and animal studies were excluded. RESULTS Bisphosphonate therapy has a significant level of importance within all dental departments, and the treatments for BRONJ are diverse without any documented superiority of one over another. CLINICAL SIGNIFICANCE Each dental specialty must be aware of the risk of BRONJ in their patients, especially elderly ones with history of bone-related therapy or tumor. No definite consensus is made for some departments due to lack of evidence and rare cases.