Orolingual angioedema associated with olmesartan use after recombinant tissue plasminogen activator treatment of acute stroke

Recombinant tissue plasminogen activator (rt-PA) may cause angioedema, especially in patients who are using angiotensinconverting enzyme (ACE) inhibitors. Risk of angioedema has been reported to be associated with ACE inhibitor use (relative risk [RR], 13.6; 95% CI, 3.0-62.7). 1 Theoretically, angiotensin receptor blockers