Abstract 16274: Prehospital Titration of Oxygen Post Resuscitation From Shockable Cardiac Arrest: Results From the Exact Pilot Study

Introduction: Hyperoxemia post-return of spontaneous circulation (post-ROSC) has been found to be harmful in animal and observational clinical studies. Previous bench-tests have suggested that oxygen at 2L/min into a bag with reservoir provides about 40% oxygen compared with 10L/min which provides 100% oxygen. We aimed to conduct a multi-centre, Phase 2 study to test whether prehospital titration of oxygen results in an equivalent number of patients arriving at the ED with oxygen saturation (O2 sat) >94% compared with the current approach of 100% oxygen administration. Methods: We enrolled adult patients with sustained ROSC from a shockable, presumed medical OHCA who were: unconscious, normoxic (O2 sat ≥95%), and had an advanced airway. Initially (Sept 2015 -March 2016) patients were allocated to either standard care (>10L/min oxygen) or titration (2L/min oxygen). However, due to a high number of desaturations (02 sat <94%), the titrated arm was changed (April 2016-current) to a reduction of oxygen to 4L/...