Maximum permissible concentrations and negligible concentrations for phthalates (dibutylphthalate and di(2-ethylhexyl)phthlate), with emphasis on endocrine disruptive properties
1999
This report presents maximal permissible concentrations (MPCs) and
negligible concentrations (NCs) are derived for di-n-butylphthalate (DBP)
and di(2-ethylhexyl)phthalate (DEHP). Phthalates are often mentioned as
suspected endocrine disrupters. Data with endpoints related to the
endocrine or reproductive system for in vitro as well as in vivo tests
were collected. Especially the two-generation reproduction studies were
found sensitive in detecting endocrine disruptive effects. None of the
tests with uterine weight (often in combination with vaginal
cornification) showed positive results. The most sensitive endpoints in
the in vivo studies are converted to concentrations in the organic carbon
exerting adverse effects. Based on the available data, the MPCs derived
using classical endpoints (survival, growth and reproduction) are
concluded to give sufficient protection against adverse endocrine
disruptive effects.
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