BRCA2 susceptibility gene breast cancer linked to chromosome 13.

The present invention generally refers to the field of human genetics. Specifically, the present invention relates to methods and materials used to isolate and detect a gene predisposing human breast cancer (BRCA2), some mutant alleles CAUSING susceptibility to cancer, particularly breast cancer. Specifically, the invention relates to MUTACIONES germline BRCA2 GENE AND ITS USE IN THE DIAGNOSIS OF BREAST CANCER predisposition. The present invention further relates to Somatic Mutations in BRCA2 GENE IN HUMAN BREAST CANCER AND THEIR USE IN DIAGNOSIS AND PROGNOSIS OF THE HUMAN BREAST CANCER. IN ADDITION, THE invention relates to Somatic Mutations in BRCA2 GENE IN HUMAN CANCERS AND OTHER USE IN DIAGNOSIS AND PROGNOSIS OF THE HUMAN CANCERS. The invention also relates to HUMAN CANCERS THERAPY HAVING A BRCA2 gene mutation, GENE THERAPY INCLUDING, replacement therapy MIMETICA PROTEIN AND PROTEIN. The invention further relates to drug research for cancer therapy. Finally, the invention relates to the investigation of BRCA2 gene mutations, which is useful for diagnosing the predisposition to breast cancer.