Hypertrophic osteopathy and bone metastases in a dog with prostatic carcinoma

portuguesOs carcinomas prostaticos em caes sao neoplasmas agressivos e as metastases osseas podem ocorrer, entretanto a associacao com osteopatia hipertrofica e pouco relatada. Um canino, macho, sem raca definida de 10 anos de idade, com historico de claudicacao e aumento de volume em membro pelvico esquerdo, apresentou no exame radiografico uma massa ossea, litica em metatarso esquerdo, bem como reacao periosteal proliferativa difusa em diversos ossos do esqueleto apendicular alem de estruturas nodulares, radiopacas em todos os lobos pulmonares. Realizou-se o diagnostico presuntivo de neoplasia ossea primaria com metastases pulmonares e osteopatia hipertrofica e iniciou-se o tratamento quimioterapico. Todavia, nao houve resposta clinica satisfatoria, optando-se pela eutanasia. Na necropsia foi constatado aumento de volume moderado da prostata, com aspecto multilobulado, ao corte firme e brancacento. Diversas massas similares foram observadas no rim direito, pulmoes, linfonodos mediastinicos e em varios ossos do esqueleto apendicular, alem de evidente reacao periosteal difusa. A avaliacao histologica revelou um carcinoma prostatico metastatico com envolvimento osseo, bem como osteopatia hipertrofica pulmonar. Esse relato e um caso incomum de carcinoma prostatico metastatico devido a associacao com osteopatia hipertrofica pulmonar e as metastases osseas concomitantes EnglishProstatic carcinomas in are aggressive neoplasms and bone metastases may occur; however, hypertrophic osteopathy associated with that condition is poorly documented. A ten-year-old, neutered male, mixed breed dog had a history of lameness and volume increase in the left pelvic limb. On radiographic examination, a lytic bone mass was observed in the left metatarsus, as well as a diffuse proliferative periosteal reaction in several bones of the appendicular skeleton, in addition to radiopaque nodular structures in all lung lobes. A presumptive diagnosis of primary bone neoplasia with pulmonary metastases and hypertrophic osteopathy was established and chemotherapy treatment was started. However, there was no satisfactory clinical response, and euthanasia was ellected. At necropsy, there was moderate enlargement of the prostate gland. The gland was firm and whitish, with a multilobulated aspect. Several similar masses were observed in the right kidney, lungs, mediastinal lymph nodes, and multiple bones of the appendicular skeleton. These bones also presented evident diffuse periosteal reaction. Histological examination revealed a metastatic prostatic carcinoma with bone involvement and hypertrophic osteopathy. This report is an unusual case of metastatic prostatic carcinoma in association with hypertrophic osteopathy and concomitant bone metastases