Protonation Constants of Some N-Substituted Amidoximes in a 50% Ethanol-Water Mixture (v/v)

The stoichiometric protonation constants of some N-substituted amidoximes have been determined potentiometrically in a 50% ethanol-water mixture (v/v) at 25°C and at constant ionic strength. A calculation was peformed using a PC software. The variation of the protonation constants of these compounds was interpreted on the basis of structural effects exposed by the substituents and main skeleton.