A kind of silver nanoclusters sensor and its preparation method and application
2016
The present invention provides a kind of silver nanoclusters sensor and its preparation method and application, which is DNA fluorescent optical sensor, and the DNA is molecular beacon type multifunctional dna sequence, has quencher its 3' is terminal modified.Preparation method includes design multifunctional dna sequence, forms molecular beacon type DNA sequence dna and prepare three steps of silver nanoclusters sensor.The sensor can be used for DNA bio-sensing and such as detect gene order, apply also for aptamers sensing such as detection small-molecule substance and macromolecular substances.Only after identifying determinand, the signal extinguished originally is just activated silver nanoclusters sensor of the invention, to carry out that fluorescence detection can be activated, to remove washing step from and improve the sensitivity of detection.
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