Abstract 17280: The Effect of Long-Term Administration of PGE1 on the Morphological Change of Ductus Arteriosus

Introduction: Plostagrandin E1 (PGE1) is essential to maintain the ductus arteriosus (DA) in ductal-dependent congenital heart diseases. Recently, relatively long-term administration of PGE1 became common, especially in patients with hypoplastic left heart syndrome (HLHS). Staged Norwood approach which consists of PGE1 infusion, bilateral pulmonary artery banding and Norwood procedure provided excellent survival benefit. However, microstructural changes in DA after long-term PGE1 administration remains unknown. Therefore, we sought to investigate their features of DA after long-term PGE1infusion using synchrotron based X-ray phase-contrast tomography (XPCT), a novel modality to inspect biological soft tissue and pathological scrutiny including DA specific immunostaining. Methods: Seventeen DA tissues of HLHS were obtained during Norwood procedure. The median duration of PGE1 was 48 days (Range 3-123). Radiographic microstructural analysis of DA was performed using XPCT at SPring-8 (Hyogo, Japan). Histolog...