[Central hemodynamics, effectiveness of endocardial blood flow and general physical work capacity in impaired glucose tolerance and diabetes mellitus].

: The end diastolic pressure, myocardial viability index and other parameters of myocardial contractility, as well as central hemodynamics and general physical working capacity were studied in 120 subjects, including 20 subjects with impaired glucose tolerance, 80 patients with diabetes mellitus, and a control group of 20 healthy subjects. In impaired glucose tolerance, a tendency to reduced endocardial blood flow and myocardial contractility as well as elevated end diastolic pressure were observed. The physical working capacity remained within normal. In decompensated diabetes mellitus, the efficacy of endocardial blood flow considerably reduced, the end diastolic pressure rose more than twofold, myocardial contractility deteriorated, the stroke volume decreased, the general physical working capacity sharply fell. In compensated diabetes mellitus, versus decompensated one, subendocardial perfusion and myocardial contractility improved, stroke volume increased; the exercise tolerance threshold rose but did not reach normal.