成分献血時に用いる抗凝固剤SCS-4 (4%クエン酸ナトリウム液) の有用性の検討

ACD-A solution, anticoagulant for preserved blood, has been used for donor plasmapheresis (DP), howerver it has some undesirable problems for the puropose.This time, we examined usefulness of SCS-4 (4% sodium citrate solution, USP XXI) as an anticoagulant for DP in 85 healthy volunteers, 75 cases by membrane method and 10 cases by centrifugal method.SCS-4 was safely used as an anticoagulant for DP in both methods, in less volume than the conventional ACD-A solution because of the higher citrate concentration. The blood picture, biochemistry, coagulation factors and immunoglobulin of the donors returned normal promptly in both methods. We could obtain plasma with high concentration of total protein, albumin, immunoglobulin and coagulation factors.These results indicate that SCS-4 is useful as an anticoagulant for DP.