Nevus Cells and Special Nevomelanocytic Lesions in Children

Nevomelanocytic lesions in children represent a wide spectrum of proliferative neurocristopathies, ranging from the common small and benign congenital nevi to the garment-type congenital lesions. Included in this spectrum are some rare entities like neurocutaneous melanocytosis, malignant melanoma simulants, and special variants of congenital pigmented nevi. Here, we analyze some tissue culture characteristics of nevomelanocytic cells from giant and small congenital nevi, neuro-cutaneous melanocytosis, and a rare variant of nevus named “bulky nevocytoma.” Correlations with their histological, immunohistochemical, and ultrastructural features are addressed.