IGFBP7 for the diagnosis of diastolic dysfunction

Method of diagnosis and / or gradation of diastolic dysfunction and / or at least one abnormality structure or functional heart associated with diastolic dysfunction in a patient suffering from heart failure, said method comprising the steps of: a) measuring level IGFBP7 (protein 7 factor binding insulin-like growth) in a sample of a patient suffering from heart failure, wherein said patient has ventricular ejection fraction (LVEF) reduced b) comparing the level of IGFBP7 measured in a) with a reference level, wherein the structural or functional abnormality associated with diastolic dysfunction is selected from the group consisting of an E '/ a' increased, an increased size of the left atrium, one index increased left atrial volume, increased peak speed E, peak A low speed, ratio E / A transmitral increased, pr oporcion E / E 'increased, peak systolic velocity of reduced pulmonary vein peak diastolic velocity of increased pulmonary vein, systolic / diastolic ratio of reduced pulmonary vein, right ventricular increased surface area, increased systolic right ventricular pressure (RVSP), increased right ventricular dilation, increased size of the right atrium, mitral regurgitation more than mild tricuspid regurgitation and more than mild.