Nonadditivity in Human Microsomal Drug Metabolism Revealed in a Study with Coumarin 152, a Polyspecific Cytochrome P450 Substrate.

We closely characterized 7-Dimethylamino-4-trifluromethylcoumarin (Coumarin 152, C152), a substrate metabolized by multiple P450 species, to establish a new fluorogenic probe for the studies of fun...