Two novel compounds with antitumor effects in Rubus corchorifolius leaves, preparation method and application thereof

The invention relates to two novel compounds separated out by extracting Rubus corchorifolius leaves and a preparation method thereof. The two novel compounds are obtained through adopting methods of repeated silicagel column chromatography, thin layer chromatography and crystallization in the crude extract of the Rubus corchorifolius leaves, wherein the chemical name of the compound I is (ZM-1) 3beta, 16alpha, 17, 19-tetrahydroxy-ent-kaurene-19-acetate, and the chemical name of the compound II is (99-106) 3beta, 16alpha, 17,19-tetrahydroxy-ent-kaurene-19-acetate-17-O-beta-D-glucoside. Proved by an activity experiment, the two novel compounds have very good antitumor effects, and can be applied to preparing antitumor drugs.