Isostructural Metabolites of Two Anti‐Parkinson Drugs

The absolute configurations of desmethylselegiline hydrochloride [(R)-(-)-1-benzyl-N-(2-propynyl)ethylammonium chloride, C 12 H 16 N + .Cl - ], (1), and p-fluoro-desmethylselegiline hydrochloride [(R)-(-)-1-(4-fluorobenzyl)-N-(2-propynyl)ethylammonium chloride, C 12 H 15 FN + .Cl - ], (2), have been determined. The two compounds are metabolites of the anti-Parkinson agent selegiline and its backup, p-fluoroselegiline. The two crystal structures are highly isostructural.