A comparison of panoramic radiographic findings in patients with Familial Adenomatous Polyposis and the general population - A multicenter study: Familial Adenomatous Polyposis: a multicenter approach

ABSTRACT Objectives . Familial Adenomatous Polyposis (FAP) is a hereditable disorder characterized by early and unremitting development of intestinal polyps and extraintestinal manifestations requiring multidisciplinary surveillance. Herein we describe a multicenter cross-sectional analysis of the dento-osseous radiographic findings of patients with FAP from North and South America. Study design . Groups I and II included FAP individuals diagnosed by standard clinical criteria. Subjects were paired with age and gender-matched, healthy, non-FAP controls. Panoramic radiograph of both cohorts, children and adults were analyzed. Results . Of 114 panoramic radiographs, 38 were from patients with FAP, composed of Group I (n=22), Group II (n=16), and 76 matched controls. Evaluators had an excellent agreement on key findings (ICC=0.89). The prevalence of osseous anomalies was higher in adults (75%) than in children (65.4%). Dental anomalies were also higher in FAP children with a prevalence of 15.4%. Conclusions . We described important and significant differences in the prevalence of dento-osseous anomalies in children compared with adult FAP patients. These findings warrant careful consideration and may influence multidisciplinary management of the condition. Conversely, the presence of these abnormalities in pediatric dental patients even if not diagnosed with FAP should be borne in mind as possibly indicating de novo or unrecognized disease.