A Direct Synthesis of Pharmacologically Active ortho-Substituted Biaryls: A Combined Directed Metalation-Palladium Catalyzed Cross Coupling Approach Using Aryl Oxazolines or Benzamides

Kevin Koch,R. J. Chambers,M. S. Biggers

A Direct Synthesis of Pharmacologically Active ortho-Substituted Biaryls: A Combined Directed Metalation-Palladium Catalyzed Cross Coupling Approach Using Aryl Oxazolines or Benzamides

1994

Kevin Koch
R. J. Chambers
M. S. Biggers

A general combined directed metalation-transmetalation-cross coupling methodology for the regiospecific preparation of biologically active ortho biaryls is described.

Keywords:

Metalation
Carboxamide
Aryl
Transmetalation
Coupling
Palladium
Catalysis
Chemistry
Organic chemistry
cross reactions
Combinatorial chemistry

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