Method for improving salicylazosulfapyridine refining production efficiency

2014 
A disclosed method for improving salicylazosulfapyridine refining production efficiency comprises: cooling a salicylazosulfapyridine suspension in a crystallization pan to 5-10 DEG C, putting in a dissolving filter to filter, pressing the material with nitrogen to dry, keeping the press-dried material in the dissolving filter, directly adding an aqueous solution of glacial acetic acid for next-step refining into the dissolving filter, stirring the solid material to be at a suspended state, and directly pressing the solid-liquid mixture into a next-step refining reaction pan, so as to finish the whole material discharging, transferring and feeding work. According to the method, the technology operation time is shortened, and all operations are performed in a sealed system. The work labor intensity is substantially reduced and operation accords with GMP requirements. Also, environmental pollution is reduced and the risk that the material is polluted because of long-term exposure is avoided.
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