Delivery by Cationic Gelatin Nanoparticles Strongly Increases the Immunostimulatory Effects of CpG Oligonucleotides

Klaus Zwiorek,Carole Bourquin,Julia Battiany,Gerhard Winter,Stefan Endres,Gunther Hartmann,Conrad Coester

Delivery by Cationic Gelatin Nanoparticles Strongly Increases the Immunostimulatory Effects of CpG Oligonucleotides

2008

Klaus Zwiorek
Carole Bourquin
Julia Battiany
Gerhard Winter
Stefan Endres
Gunther Hartmann
Conrad Coester

Purpose Cationized gelatin nanoparticles (GNPs) were used as carrier to improve delivery of immunostimulatory CpG oligonucleotides (CpG ODN) both in vitro and in vivo.

Keywords:

Oligonucleotide
Microparticle
CpG site
In vivo
Gelatin
Drug carrier
Biochemistry
Chemistry
In vitro
CpG Oligodeoxynucleotide
Cationic polymerization

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