Microwave-Assisted Protection of Phenols as tert-Butyldimethylsilyl (TBDMS) Ethers under Solvent-Free Conditions.

Abstract A facile, time‐saving procedure to protect phenols with tert‐butyldimethylsilyl chloride using imidazole as catalyst under solvent‐free conditions is described. Several phenolic compounds with different substitution patterns can be silylated in high yield with substantially reduced generation of residues, a present goal in organic synthesis.