Total Synthesis of 20-Hydroxy-hepoxilins, New Metabolites of the Hepoxilin Family.

A newly described enzymatically formed ω-hydroxy metabolite of hepoxilin A 3 (HxA 3 ) has been prepared via total synthesis involving polyacetylenic intermediates and Mitsunobu rearrangement of the intermediate putative ω-hydroxy metabolite of hepoxilin B 3 .