SAT0453 Clinical, Autoimmune and Psychiatric Parameters in Systemic Sclerosis and Rheumatoid Arthritis Patients: Correlations with Sleep Disturbances

Background Sleep disturbance has been identified as an important contributor to poor quality of life in rheumatic disorders 1 . Mood disorders and pain perception are considered the main factors influencing sleep quality. Objectives This study aims to test whether clinical, autoimmune and psychological factors are associated with sleep disturbance in systemic sclerosis (SSc) compared to rheumatoid arthritis (RA) patients and controls. Methods 101 female subjects (SSc=33, RA=34, healthy controls=34) participated in this observational, cross-sectional, parallel group study. Subjects affected by secondary fibromyalgia were excluded. Sleep disturbances have been assessed through the Pittsburgh Sleep Quality Index (PSQI). Other assessments included the visual analog scale (VAS) for pain, the Beck Depression Inventory (BDI) and the state trait anxiety inventory (STAI) Y1 and Y2. Clinical parameters, such as the modified Rodnan skin score (mRSS) for SSc and disease activity score 28 (DAS28) for RA patients, therapeutic regimen and autoantibody positivity were collected. Results A PSQI score ≥5, cut-off value for the definition of poor sleeper, was found in 94% SSc patients, in 68% RA patients and in 20% healthy controls. In SSc PSQI scores were significantly higher than RA (p 3.2, n=19) had significantly higher PSQI scores (p=0.02) than those with lower than moderate (DAS28 Conclusions The definition of specific pattern of patients with higher risk to develop sleep disturbances could allow the clinician to better approach patients and to treat potentially modifiable factors. References Abad VC et al. Sleep and rheumatologic disorders. Sleep Med Rev 2008;12:21128 Disclosure of Interest None declared