Cardiac Hypertrophy and Heart Failure Development Through Gq and CaM Kinase II Signaling

Abstract:The molecular events associated with the development of pathological hypertrophy have been shown to be stimulated through G-protein-coupled receptors that activate Gq signaling pathways in neonatal cardiomyocytes and in transgenic (TG) and knockout mice. We demonstrated that CaMKII, a multi