Quantitative bioanalytical LC–MS/MS assay for S130 in rat plasma-application to a pharmacokinetic study

Yanping Guan,Yuanyuan Fu,Yao Liu,Siyi Wang,Man Zhao,Zhongming Jin,Fulin Jiang,Liang Hong,Min Huang,Min Li,Guoping Zhong

Quantitative bioanalytical LC–MS/MS assay for S130 in rat plasma-application to a pharmacokinetic study

2019

Yanping Guan
Yuanyuan Fu
Yao Liu
Siyi Wang
Man Zhao
Zhongming Jin
Fulin Jiang
Liang Hong
Min Huang
Min Li
Guoping Zhong

Aim: An innovative Atg4B inhibitor, S130, exhibited a negative influence on colorectal cancer cells in vitro and in vivo. To assist reliable toxicodynamic and pharmacokinetic evaluation, an LC–MS/M...

Keywords:

In vivo
Bioavailability
Liquid chromatography–mass spectrometry
Chromatography
Toxicodynamics
Bioanalysis
Pharmacokinetics
Chemistry
In vitro
lc ms ms

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