Benzoquinazoline derivatives as new agents affecting DNA processing.

Abstract A new series of benzo[ h ]quinazoline and benzo[ f ]quinazoline derivatives was prepared and studied for the biological activity. The compounds carrying a dimethylaminoethyl side chain ( 6c , 8c and 12 ) inhibit cell growth. The ability to form a molecular complex with DNA and to interfere with topoII and topoI relaxation activity was evidenced for the most active 6c and 8c , along with the capacity to induce apoptosis on HeLa cells.