Sensitive Voltammetric Detection of Indomethacin Using TiO2 Nanoparticle Modified Carbon Ionic Liquid Electrode

In this work, a TiO2 nanoparticle modified carbon ionic liquid electrode (CILE) was employed as a sensitive sensor for the investigation of the electrochemical behavior of indomethacin (IND). This nanocomposite sensor has been fabricated by incorporation of TiO2 nanoparticles and the ionic liquid 1-hexylpyridinium hexafluorophosphate (HPFP). The surface of the electrode was studied by scanning electron microscopy (SEM). Differential pulse voltammetry (DPV) was used for quantification of sub-micromolar amounts of IND. Electrochemical parameters of the electrode reaction of IND, including the electron transfer coefficient (α) and the electron-transfer number (n), were calculated by cyclic voltammetry (CV) methods. Under selected conditions, the anodic peak current was linear for the concentration of IND in the broad range of 1.0 × 10-7 to 1.0 × 10-4 M with the detection limit of 2.1× 10-8 M. Moreover, the analytical performance of the proposed method for the determination of IND content in plasma samples was evaluated with good sensitivity and acceptable recoveries.