INCREASE IN THE PLASMA INSULIN ACTIVITY FOLLOWING THE CONTINUOUS INFUSION OF MESOXALATE INTO THE PANCREATIC CIRCULATION IN DOGS
1960
Sodium mesoxalate solution (1.6%) was continuously infused into dogs at the rate of 1 ml/min through the artery supplying the pancreas, and the insulin activity in plasma as well as blood sugar value was determined. It was found that the insulin activity in plasma increased to about 10 times the normal control value 6 hours after the commencement of the mesoxalate infusion. Previously, the authors have put forth the suggestion that the antidiabetic effect of mesoxalate might be attributed to the action of this drug to induce hyperinsulinemia. This suggestion has now been fully corroborated in the present experiments by direct evidence. The mode of action of this drug is also briefly discussed.
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