Analysis on family history,cinical pathology and survival for the patients with concurrent esophageal and gastric cardia cancers(n=1011)

Objective To compare the family history,clinical pathology and survival rate on the patients with concurrent esophageal squamous cell carcinoma(SCC) and gastric cardia adenocarcinoma(GCA)(CC patients) and the patients with either single SCC or GCA.Methods Home visit,questionnaire survey,hospital pathological check and telephone follow-up were performed in 1 011 patients with CC,2 095 patients with single SCC and 1 859 patients with single GCA.These patients came from the high incidence area of SCC and GCA at the junction of Henan,Hebei and Shanxi Provinces.SPSS 17.0 statistical software was used for,t-test,chi-square test,Kaplan-Meier survival analysis,Cox-regression model was used to analyze the relationship of family history,clinical pathology and survival rate between CC patients and single SCC or GCA patients.Results The positive family history rate of patients with CC was higher than those with single GCA(34%,27%,P0.05),but similar with that in the single SCC patients(34%,31%,P0.05).The early SCC and GCA from CC was more common in those with single SCC(27%∶15%) and GCA(18%,4%,P0.05).The patients with CC had shorter survival time than those with single SCC and GCA(P0.05),the mortality risk for CC was 2 folds and 3 folds higher than in those with single SCC(P0.05,HR=1.976) and GCA patients(P0.05,HR=2.652).Conclusion The hereditary susceptibility of CC patients is higher than the single SCC/GCA patients.The CC patients have shorter survival time than those with single SCC/GCA.