A kind of preparation method of Glipizide

The present invention relates to a kind of preparation methods of Glipizide for a kind of preparation method of Glipizide, and this method is with 4 [2 (5 methylpyrazine, 2 formamido groups）Ethyl] benzsulfamide be raw material, first chloro, after be obtained by the reaction in the presence of iron catalyst with carbon monoxide and cyclohexylamine.This method is simple and practicable, and the synthesis for Glipizide provides new process route.