STUDIES ON FORMULATION DEVELOPMENT, OPTIMIZATION AND IN VITRO RELEASE KINETICS OF PARACETAMOL AND ETODOLAC INDIVIDUALLY AS WELL AS IN COMBINATION FORM

The Present work was for the Formulation of Etodolac, which is practically insoluble in water, and Par acetamol which is sparingly soluble in water, as a single dosage form was a challenging task. The two different approach es were followed, one involving Separate granulation of Etodolac and Paracetamol and then mixing of two granules before compression. The second approach involved combined granulation of Etodolac and Paracetamol. There was light binding done in approach 1 of both granules and in approach 2 there was medium binding. The surfactant was added in both the approaches to aid the dissolution of Etodolac from the combination tablet. Disintegrant was added both intragranularly and extragranularly which enabled good disintegrati on of the combination tablet. Both the approaches f ollowed were able to give good Disintegration time, Hardness Friabili ty and other parameters of the tablet. Dissolution and Initial Assay values of both Etodolac and Paracetamol were found according to specifications. The three-month stabil ity study samples kept in PVC packs at 25oC and 60% RH also passes the test for Assay, Dissolution and oth er physical parameters. So it can be concluded that Etodolac and Paracetamol tabl ets formulated using both the approaches are good. The combined granulation approach is less time consuming and cos t effective.