Vitamin C-Induced Increase of Dermatan Sulfate in Cultured Hurler's Fibroblasts

1966 
In fibroblasts taken from patients witli Hurler9s syndromne and grown in cultlure, dermatan sulfate constituted a larger percentage of the total sulfated glycosaminoglycans than it did in cultured fibroblasts from unaffected individuals. Moreover, the addition of ascorbic acid (vitamnin C) to the culture medium markedly increased the concentration of dermatan sulfate in the Hurler9s fibroblasts but not in the normal fibroblasts. The biochemical phenotype of the Hurler9s cells persisted during 28 weeks of serial culture.
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