Microbial Screening of Marine Natural Product Inhibitors for the 6′-Aminoglycoside Acetyltransferase 2″-Aminoglycoside Phosphotransferase [AAC(6′)-APH(2″)] Bifunctional Enzyme by Ultra-High Performance Liquid Chromatography–Mass Spectrometry (UHPLC-MS)

Qian Wang,Li Zhu,Yi Yu,Huashi Guan,Zhe Xu

Microbial Screening of Marine Natural Product Inhibitors for the 6′-Aminoglycoside Acetyltransferase 2″-Aminoglycoside Phosphotransferase [AAC(6′)-APH(2″)] Bifunctional Enzyme by Ultra-High Performance Liquid Chromatography–Mass Spectrometry (UHPLC-MS)

2021

Qian Wang
Li Zhu
Yi Yu
Huashi Guan
Zhe Xu

Aminoglycoside antibiotics exhibit broad-spectrum antibacterial activity, good efficacy, and stability. However, due to the emergence of antibiotic resistance, their use as broad-spectrum antibioti...

Keywords:

Liquid chromatography–mass spectrometry
Antibacterial activity
Antibiotic resistance
Antibiotics
Aminoglycoside Phosphotransferase
Aminoglycoside
Chromatography
Chemistry
Natural product
Phosphofructokinase 2

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