Glioblastoma multiforme e infecção pelo HIV: associação coincidente ou possível influência oncogênica?

O glioblastoma multiforme e o tumor cerebral primario glial mais maligno em adultos e de altaincidencia dentre os tipos de astrocitomas, mas geralmente nao e incluido no diagnostico diferencial das lesoes do sistema nervoso central em pacientes com o virus da imunodeficiencia humana (HIV). Alguns estudos tem descrito a associacao entre glioblastoma e HIV. Relato do caso: Trata-se de glioblastoma em um homem de 31 anos de idade com HIV. Outras possiveis lesoes, como o linfoma, foram sugeridas como diagnostico diferencial, mas a investigacao histopatologica confirmou tratar-se de glioblastoma. Esse paciente, submetido a cirurgia, evoluiu bem, sem deficits neurologicos no pos-cirurgico imediato, e exames clinicos e de neuroimagem nao mostraram sinais de recorrencia ate tres meses de pos--operatorio. Terapia adjuvante com radiacao externa foi recomendada para o paciente. Glioblastoma multiforme is the most malignant primary brain glial tumour in adults with high incidence among astrocytomas, but usually it is not included in the differential diagnosis of the central nervous system lesions in patients with Human Immunodeficiency Virus (HIV). Some studies have described the association of glioblastoma and HIV. Case report: It is reported a case of glioblastomas in a 31 year old man with HIV. Mass lesions such as lymphoma were suggested as differential diagnosis, but the histopathology confirmed the diagnosis of glioblastoma. This patient was operated with good neurological evolution immediately after surgery; no clinical or neuroimaging signs of recurrence were observed up to 3 months post-operatively. Adjuvant external radiation therapy was commenced for the patient.