Hemoglobina glicosilada en pacientes no diabéticos y su relación con la enfermedad arterial coronaria

Introduction Glycosylated hemoglobin correlates with micro- and macrovascular complications in patients in patients with diabetes. It is also associated as a predictor in the detection of coronary artery disease. However in non-diabetes patients its role has not been extensively evaluated. Objective : To evaluate the relation of glycosylated hemoglobin in the appearance of coronary artery disease and his severity. Method : An observational longitudinal study was conducted in non-diabetes patients that were undergoing coronary angiography in Hermanos Ameijeiras Hospital from september 2011 to 2012. Previous procedure glycosylated hemoglobin was measured. Results 60 years, masculine gender (80%) and white skinned (68 %) were predominant (p=0,00). High blood pressure (65 %) and smoking habit (41 %) were the most frequent risk factors (p=0,00 y p= 0,05 respectively). Patients with multi vessel coronary disease had higher level of glycosylated hemoglobin (p=0,005). We obtained an area under the ROC curve of 0,78 and a cut point of 4,35 with a sensibility of 72 % and a specificity of 82 % in the prediction of coronary artery disease Conclusion : HbA1c is useful in prediction of coronary artery disease and its severity. Keyword: Glycosylated hemoglobin, Coronary artery disease, Risk factors, Non-diabetes patients.