994 Association of 13-cis-retinoic acid (13CRA) and alpha-interferon-2A (IFN- α 2A) in moderate-severe cervical intraepithelial neoplasia

Recent studies both in vitro and in vivo have suggested a possible synergism between IFN- α 2a and 13cRA. The specific aim of our study was to evaluate efficacy and toxicity of the association of these two agents in patients (pts) with CIN II and III. 13cRA (orally at 0.5–1 mg/kg/day) and IFN- α 2a (i.m. at 3 millions I.U) were administered simultaneously for 8 consecutive weeks. 22 pts (aged 25 to 58 years), of which 14 CIN II and 8 CIN III, entered the study. 14/22 (64%) histologically verified OR (7 CR and 7 PR were achieved). In addition, 8 SD were recorded. Compliance was generally good and no delays due to toxicity were recorded.