[Hand-Schüller-Christian syndrome arising in the mandible. A case report].

: The history of Letterer-Siwe, Hand-Schuller-Christian disease, and eosinophilic granuloma of the bone, and the evolution of the concept of grouping them together under the common term of histiocytosis X are presented. The characteristics of the disease, with particular emphasis on oral manifestations, are reviewed. The therapy for the disease is briefly outlined. One case of Hand-Schuller-Christian syndrome is presented. The discussion is focused on the problem of chemotherapy in disseminated forms.