Characterization of a Phenotypically Unique Population of CD13+ Dendritic Cells Resident in the Spleen

Immature dendritic cells (DCs) resident in bovine spleens represent a distinct CD11a + CD11c + CD13 + CD172 + CD205 + population compared to those circulating in peripheral blood or trafficking via afferent lymph. Upon cytokine-induced maturation, splenic DCs both efficiently present antigen in the stimulation of allogeneic lymphocyte proliferation and recall antigen-specific responses.