[Effect of food carbohydrate quality on monosaccharide utilization for the biosynthesis of glycogen, fat and proteins in the rat liver]

The inclusion of 3H-6-glucose and 14C-fructose metabolites into the rat liver glycogen, lipids and protein was studied in male rats receiving the rations containing 56% of carbohydrates, 18% protein, 26% fat, necessary amount of mineral substances and vitamins, during 25 days. Animals given the ration with starch, as a carbohydrate, were used as controls. In the ration of animals in groups 2, 3 and 4 some portion of starch (30% calorific value) was substituted for glucose, sucrose of the mixture of glucose and fructose (1:1). It was found that in the liver of animals given pure starch, radioactivity from 3H-6-glucose was included mainly into proteins, when starch was partly substituted for monosaccharide--mainly into lipids. These regularities were recorded in the distribution of radioactivity from 14C-fructose, all the parameters being shifted in the direction of increased inclusion of radioactivity into lipids. Partial substitution of starch for sucrose specifically changed the radioactivity distribution between proteins and lipids, thus revealing a distinct "disaccharide" effect.